KAchannels reduce dendritic depolarization from synchronized synaptic input: implication for neural processing and epilepsy
نویسندگان
چکیده
منابع مشابه
Effects of Neural Morphology and Input Distribution on Synaptic Processing by Global and Focal NMDA-Spikes
Cortical neurons can respond to glutamatergic stimulation with regenerative N-Methyl-D-aspartic acid (NMDA)-spikes. NMDA-spikes were initially thought to depend on clustered synaptic activation. Recent work had shown however a new variety of a global NMDA-spike, which can be generated by randomly distributed inputs. Very little is known about the factors that influence the generation of these g...
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BY MEANS OF COMPUTATIONAL EXPERIMENTS with a mathematical neuron model, it is possible to make many detailed predictions, some of which can be tested by comparison with suitably controlled experimental observations. In particular, a theoretical model which permits a choice of both the time course and the soma-dendritic location of synaptic input, makes it possible to explore the way in which th...
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We examined the hypothesis that dendritic voltage-gated channels can reduce the effect synaptic location has on somatic depolarization in response to patterns of short synaptic trains (referred to as location-dependent variability). Three computer models of a reconstructed hippocampal CA1 cell, each of increasing realism and complexity, were used. For each model, the goal was to identify the de...
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An important task performed by a neuron is the selection of relevant inputs from among thousands of synapses impinging on the dendritic tree. Synaptic plasticity enables this by strenghtening a subset of synapses that are, presumably, functionally relevant to the neuron. A different selection mechanism exploits the resonance of the dendritic membranes to preferentially filter synaptic inputs ba...
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ژورنال
عنوان ژورنال: BMC Neuroscience
سال: 2008
ISSN: 1471-2202
DOI: 10.1186/1471-2202-9-s1-p45